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内源性阿片样物质(endogenous opiate substance,EOS)在中枢及外周广泛分布,对机体功能产生多方面影响。就其心血管效应而言,休克等应激状态 EOS水平明显升高,可在心血管中枢、交感神经节、交感神经末梢膨体、肾上腺髓质及心血管效应器官等多个环节程度不同地影响交感-肾上腺髓质系统的活性,参与抑制心血管功能。纳洛酮等阿片受体阻断剂可能通过上述环节程度不等地拮抗 EOS 的作用,部分改善休克个体的心血管功能而表现出一定的抗休克效应。
Endogenous opioid (endogenous opiate substance) is widely distributed in the central and peripheral areas and has various effects on the function of the body. In terms of their cardiovascular effects, the level of EOS in stress states such as shock is significantly increased, and may be affected at various levels in the cardiovascular center, sympathetic ganglia, sympathetic nerve endings, adrenal medulla, and cardiovascular effector Sympathetic - adrenal medulla system activity, involved in the inhibition of cardiovascular function. Naloxone and other opioid receptor blockers may antagonize the effect of EOS by varying degrees, and partially improve the cardiovascular function of individuals with shock and show some anti-shock effects.