论文部分内容阅读
神经生长因子(NGF)最初是在研究某种小鼠纤维肉瘤有促进生长效应的过程中发现的,移植到鸡胚体壁的小鼠肉瘤组织可使感觉神经节和交感神经节的体积增加。这种肿瘤是由感觉神经和交感神经纤维密集支配的,它的效应是由肉瘤组织产生的一种激素因子所致。此后,建立了一个半定量的特异性的生物检定方法,即通过观察对离体鸡胚感觉神经节培养使神经纤维增生的能力来测定各种动物的组织或体液中的NGF,并且发现成熟雄性小鼠的颌下腺中含有浓度非常高的NGF,是分离NGF
Nerve growth factor (NGF) was first discovered in the study of the growth promoting effect of certain mouse fibrosarcoma. Mouse sarcoma tissue transplanted into the body wall of chicken embryos increased the volume of sensory and sympathetic ganglia. This tumor is closely dominated by the sensory and sympathetic fibers, and its effect is caused by a hormone produced by sarcoma tissue. Since then, a semi-quantitative, specific bioassay has been developed that measures NGF in tissues or body fluids of various animals by observing the ability to sensitize the sensory ganglia cultured in vitro to nerve fiber proliferation and to find that mature males Mice submandibular glands contain very high concentrations of NGF, NGF is isolated