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目的探讨CT引导下~(125)I粒子组织间植入治疗晚期非小细胞肺癌的临床效果。方法选取2012年9月至2014年6月间海南省海口市人民医院收治的100例晚期非小细胞肺癌患者,在CT引导下植入~(125)I,术后2个月和6个月时复查胸部CT评估疗效,观察患者术后并发症。结果植入病例全部成功,术后13例患者达完全缓解(CR),55例患者部分缓解(PR),20例患者稳定(SD),12例患者为进展(PD),总有效率达到88.0%,1年生存率为59.0%,中位无疾病进展时间为12个月。术后并发症:气胸7例,痰中带血9例,胸腔积液9例,白细胞下降4例,经对症处理均好转。结论 CT引导下~(125)I粒子组织间植入治疗晚期非小细胞肺癌疗效好,无严重并发症。
Objective To investigate the clinical effect of CT-guided 125 I seed implantation in the treatment of advanced non-small cell lung cancer. Methods A total of 100 patients with advanced non-small cell lung cancer admitted to Haikou People’s Hospital of Hainan Province from September 2012 to June 2014 were enrolled in the study. CT guided 125I I, 2 months and 6 months after operation Review chest CT assessment of curative effect, observe the patient’s postoperative complications. Results All the cases were successfully implanted, with complete remission (CR) in 13 patients, partial remission (PR) in 55 patients, stable (SD) in 20 patients and progression (PD) in 12 patients. The total effective rate reached 88.0 %, 1-year survival rate was 59.0%, the median progression-free disease time was 12 months. Postoperative complications: pneumothorax in 7 cases, sputum bloody in 9 cases, pleural effusion in 9 cases, leukopenia in 4 cases, the symptomatic treatment were improved. Conclusion The CT-guided implantation of ~ (125) I seeds in the treatment of advanced non-small cell lung cancer has good curative effect and no serious complication.