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苏文氏合剂(Solven’s Misturae)是我院临床上常用制剂之一。处方中主要含有氯化铵及甘草流浸膏、氯化铵水溶液呈酸性;而甘草流浸膏含甘草甜素(即甘草酸钠、钾、钙盐)。当两者混合时,因氯化铵的酸性可使甘草甜素转变为水溶性较小的甘草酸析出,因而在配制时常加入氨水以防止沉淀。但在实际工作中,虽加氨水,仍未能如愿以偿。为此,我们在原处方中加入1%枸橼酸钠,可有效地防止沉淀析出。
Solven’s Misturae is one of the commonly used clinical preparations in our hospital. The prescription contains ammonium chloride and licorice extract, ammonium chloride aqueous solution is acidic; licorice extract contains glycyrrhizin (glycyrrhizin sodium, potassium, calcium salt). When the two are mixed, glycyrrhizin is converted to glycyrrhizin, which is less water-soluble, due to the acidity of ammonium chloride, so ammonia water is often added to prevent precipitation. However, in actual work, although ammonia water is added, it still fails to do what he wants. To this end, we add 1% sodium citrate in the original prescription, which can effectively prevent precipitation.