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目的比较拓扑替康(金喜素,TPT)联合顺铂与EP方案治疗小细胞肺癌的临床疗效和毒副作用。方法患者分成两组,TP组26例,TPT每日0.75 mg/m2 ~ 1.2 mg/m2,静脉滴注,第1天～第3天,顺铂40 mg/d,静脉滴注第1天～第3天,3周为1周期。EP组26例,VP16 100 mg/d,静脉滴注,第1天～第3天,顺铂同上,3周为1周期。结果TP组26例,CR率11.54 %,PR率65.38 %,有效率(RR)76.92 %,EP组CR率为0,PR率73.08 %,有效率73.08 %。主要毒副反应为血液学毒性及消化道反应。结论TPT联合顺铂治疗小细胞肺癌临床效果好,虽然毒副反应较大,但值得进一步研究。
Objective To compare the clinical efficacy and side effects of topotecan (TP) with cisplatin and EP regimen in the treatment of small cell lung cancer. Methods The patients were divided into two groups: TP group (n = 26) and TPT 0.75 mg / m 2 ~ 1.2 mg / m 2 daily. Intravenous drip, day 1 to day 3, cisplatin 40 mg / d, Day 3, 3 weeks for a cycle. EP group, 26 cases, VP16 100 mg / d, intravenous drip, the first day to the third day, cisplatin as above, three weeks for a cycle. Results In the TP group, the CR rate was 11.54%. The PR rate was 65.38%. The effective rate was 76.92%. The CR rate was 0 in the EP group. The PR rate was 73.08% and the effective rate was 73.08%. The main toxicities are hematologic toxicity and digestive tract reaction. Conclusion TPT combined with cisplatin in the treatment of small cell lung cancer clinical effect is good, although the toxicity, but worth further study.