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顺—双氯双氨络铂为无机的金属络合物,我省医药工业公司佛山制药厂合成后经中山医学院肿瘤研究所药物治疗室进行动物抑瘤试验,发现对动物移植性肿瘤大鼠W—256、小鼠肝癌、S_(180)、U_(14)等四种瘤株有明显的抑瘤作用,其抑制率达到61～96%,从而推荐临床试用。我院从1975年以来以佛山制药厂提供的顺—双氯双氨络铂(简称PDD,以下同)治疗鼻咽癌,获得显著疗效,现将资料较完整的32例鼻咽癌的治疗情况报告如下:
The cis-dichloro-bis-ammine platinum complex is an inorganic metal complex. After being synthesized by the Foshan Pharmaceutical Factory of our province’s pharmaceutical industry company, the tumor treatment experiment was carried out in the drug treatment room of the Cancer Research Institute of the Sun Yat-Sen Medical College. The animal transplanted tumor was found in rats. W-256, mouse hepatocellular carcinoma, S_ (180), U_ (14) and other four tumor strains have significant anti-tumor effect, the inhibition rate of 61 to 96%, and thus recommend clinical trials. Since 1975, our hospital has treated cis-dichloro-bis-amminoplatinum (PDD for short), which is provided by Foshan Pharmaceutical Factory, for nasopharyngeal carcinoma, and has achieved remarkable curative effect. Now we have more complete information on the treatment of 32 cases of nasopharyngeal carcinoma. The report is as follows: