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本文研究了西沙比利对大鼠胃粘膜损伤的影响和对胃粘膜—氧化氮含量分泌的影响 ,结果表明 :加入无水乙醇后 ,西沙比利 1mg/kg组胃粘膜溃疡面积及溃疡深度显著低于空白对照组 ( 10 .2± 6.9mm2 vs 2 6.1± 13.5mm2 )( 18%± 3%vs 5 0 %± 2 7% ) (P <0 .0 5 ) ,西沙比利 0 .5mg/kg组溃疡深度 ( 39%± 11% )和 2mg/kg组溃疡深度 ( 18%±7% )亦显著低于空白对照组 (P <0 .0 5 )。给予西沙比利 1mg/kg后 ,其大鼠一氧化氮 ( 2 3.32± 7.40 μmol/mg)显著高于空白对照组 ( 16.93± 3.87μmol/mg) (P <0 .0 5 )。加入西沙比利 2mg/kg后 ,大鼠胃粘膜一氧化氮含量 ( 4.35± 1.5 2μmol/mg)显著低于空白对照组 (P <0 .0 5 )。西沙比利 0 .5mg/kg组一氧化氮含量与空白对照组间差异无显著意义( 16.76± 1.0 6μmol/mg) (P >0 .0 5 )。西沙比利 1mg/kg组胃HCO3-分泌率显著升高 ( 2 0 2 %± 60 %vs 119%± 40 % )。空白对照组和西沙比利 0 .5mg/kg组无此变化。西沙比利 1mg/kg组加入无水乙醇 30分钟后HCO3-恢复率为 810 %± 2 2 0 % ,与加入无水乙醇 15分钟比较 ( 12 0 0 %± 40 0 % )差异有显著意义 (P <0 .0 5 )。西沙比利 2mg/kg组HCO3-分泌率显著降低 ( 68%± 37%vs 12 7%± 2 7% ) (P <0 .0 5 ) ,加入无水乙醇 30
In this paper, the effect of cisapride on gastric mucosal lesion and the effect on gastric mucosa-nitric oxide secretion was studied. The results showed that gastric ulcer area and ulcer depth were significantly increased in cisapride 1 mg / kg group after addition of absolute ethanol Was lower than that of the blank control group (10.2 ± 6.9mm2 vs2 6.1 ± 13.5mm2) (18% ± 3% vs50% ± 27%) (P <0.05), cisapride0.5mg / The ulcer depth (39% ± 11%) and 2mg / kg group ulcer depth (18% ± 7%) were also significantly lower than that of the blank control group (P <0.05). Nitric oxide (2 3.32 ± 7.40 μmol / mg) was significantly higher than that of the blank control group (16.93 ± 3.87 μmol / mg) (P <0.05) after cisapride administration at 1 mg / kg. The content of nitric oxide in gastric mucosa of rats (4.35 ± 1.5 2μmol / mg) was significantly lower than that of the blank control group (P <0.05) after adding cisapride 2mg / kg. No significant difference was found between the content of nitric oxide in the cisapride 0.5 mg / kg group and the blank control group (16.76 ± 1.0 6 μmol / mg) (P> 0.05). In the cisapride 1 mg / kg group, gastric HCO3-secretion rate was significantly increased (202% ± 60% vs 119% ± 40%). The blank control group and cisapride 0 .5mg / kg group did not change. The recovery rate of HCO3- was 810% ± 220% after 30 minutes of addition of absolute ethanol in cisapride 1 mg / kg group (12 0% ± 40 0%) compared with 15 minutes of addition of absolute ethanol P <0. 05). The rate of HCO3-secretion in cisapride 2 mg / kg group was significantly lower (68% ± 37% vs 12 7% ± 27%) (P <0.05), and absolute ethanol 30