消化性溃疡是一种慢性疾病,具有自然缓解和反复发作的特点。近年来对消化性溃疡病的自然史有进一步的了解:第一是内镜的应用,使溃疡得到更好的确认;第二是安慰剂作对照的临床试验提供了不用药物治疗时的溃疡复发资料。用H_2受体拮抗剂西米替丁、雷尼替丁或法莫替丁治愈的溃疡,停药后一年中胃溃疡(GU)和十二指肠溃疡(DU) Peptic ulcer is a chronic disease characterized by natural remission and recurrent attacks. In recent years, the natural history of peptic ulcer disease have further understanding: the first is the application of endoscopy, so that ulcers get better recognition; the second is placebo as a control clinical trial provides ulcer recurrence without drug treatment data. Ulcer healing with H 2 receptor antagonist cimetidine, ranitidine or famotidine, gastric ulcer (GU) and duodenal ulcer (DU) in the first year after discontinuation