中风以其高发病率、高死亡率、高致残率已经成为严重威胁人类生命与健康的主要疾病之一[1]。在现代科学研究中,小鼠局灶性脑缺血模型因为能够很好的模拟人类中风后缺血区脑梗死以及偏瘫症状。又结合当今广泛开展的转基因技术以及基因敲除技术,在研究药物治疗中风以及寻找新药靶点方面有独到的优势,因此被广泛应用[2]。但是,小鼠颅内血管的解剖结构以及线栓入颅后所走路线却从未有人报道,本研究通过展示小鼠颅内血管铸型以及线栓堵住大脑中动脉后的颅底解剖照片,来展示局灶性脑缺血模型 Stroke, with its high incidence, high mortality and high morbidity, has become one of the major diseases that threaten human life and health [1]. In modern scientific research, focal cerebral ischemia model in mice is able to simulate cerebral ischemic stroke and hemiplegia after stroke. It is also widely used in combination with the widely used transgenic technologies and gene knockout technologies today. It has unique advantages in studying drug-induced stroke and finding new drug targets [2]. However, the anatomical structure of the intracranial blood vessels of mice and the route of the line inserted into the skull have never been reported before. In this study, the skull base anatomy was shown by showing the intracranial blood vessel molds of mice and blocking the middle cerebral artery with a thread plug , To demonstrate focal cerebral ischemia model