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目的:分析降钙素原(PCT)和C-反应蛋白检测在小儿发热性疾病中的临床意义。方法:将2010年6月～2011年6月在吉林省人民医院诊治的130例发热性疾病患儿随机分为细菌感染组和非细菌感染组,分别检测每位患儿的血清降钙素原(PCT)、C-反应蛋白(CRP)及白细胞计数水平。结果:69例细菌感染患儿血清PCT和CRP质量浓度升高,差异均有统计学意义,但PCT更明显(P<0.01),非细菌感染组PCT阳性率为13%,与细菌感染组比较差异有统计学意义(P<0.01),PCT的敏感度与CRP相同,均为100%,而特异性为78%,优于CRP。结论:与CRP及白细胞计数相比较,PCT是寻找发热性疾病病因的重要生化检查,是区别细菌感染及非细菌感染的有效标准,特异性明显高于CRP及白细胞计数,可指导临床发热性疾病的诊断及抗生素的合理应用。
Objective: To analyze the clinical significance of procalcitonin (PCT) and C-reactive protein in children with febrile disease. Methods: 130 children with fever were diagnosed and treated in Jilin Provincial People’s Hospital from June 2010 to June 2011. The children were randomly divided into bacterial infection group and non-bacterial infection group. Serum procalcitonin (PCT), C-reactive protein (CRP) and white blood cell count levels. Results: The serum concentrations of PCT and CRP in 69 cases of bacterial infection were significantly higher than those of the control group (P <0.01). The positive rate of PCT in non-bacterial group was 13% The difference was statistically significant (P <0.01). The sensitivity of PCT was the same as that of CRP, both of which were 100% and the specificity was 78%, which was better than CRP. CONCLUSION: Compared with CRP and leucocyte count, PCT is an important biochemical test for finding the cause of febrile disease. It is a valid standard to distinguish between bacterial infection and non-bacterial infection. The specificity of PCT is significantly higher than that of CRP and leucocyte count, which can guide clinical febrile disease Diagnosis and rational use of antibiotics.