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目的探讨原发性高血压患者糖代谢异常与APN及颈动脉粥样硬化的关系。方法纳入150例原发性高血压患者,根据FPG和75gOGTT检测结果分为糖耐量正常(NGT)组、IGT组和DM组。ELISA检测3组血清APN水平,彩色多普勒超声检测颈动脉内膜-中层厚度(IMT)及粥样斑块,并进行比较。结果 3组间APN、IMT比较,差异均有统计学意义(P<0.05)。APN与SBP、DBP、FPG、2hPG、IMT呈负相关。多元逐步回归分析显示SBP、2hPG是影响APN水平的独立因素。结论原发性高血压患者合并不同程度糖代谢异常,其严重程度与血清APN、IMT相关。
Objective To investigate the relationship between abnormal glucose metabolism and APN and carotid atherosclerosis in patients with essential hypertension. Methods A total of 150 patients with essential hypertension were enrolled and divided into normal glucose tolerance (IGT) group, IGT group and DM group according to the results of FPG and 75gOGTT. Serum levels of APN were measured by ELISA. Carotid intima - media thickness (IMT) and plaque were detected by color Doppler sonography and compared. Results There were significant differences in APN and IMT between the three groups (P <0.05). APN and SBP, DBP, FPG, 2hPG, IMT was negatively correlated. Multiple stepwise regression analysis showed that SBP and 2hPG were independent factors affecting APN level. Conclusion Patients with essential hypertension complicated with varying degrees of abnormal glucose metabolism, the severity of which is associated with serum APN and IMT.