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目的:探讨血清C -反应蛋白/前白蛋白比值（CRP/PA）对成人颅脑外伤患者病情进展的预测价值。方法:采用前瞻性研究方法，选择2018年5月至2019年12月复旦大学附属华山医院北院急诊科收治的年龄≥18岁且急诊留观随访时间≥72 h的颅脑外伤患者。分别于伤后即刻及伤后6、24、48和72 h测定血清CRP、PA水平，计算CRP/PA比值，动态对患者行格拉斯哥昏迷评分（GCS）并定时复查颅脑CT。若患者伤后72 h内出现GCS下降≥3分和（或）颅脑CT显示颅内损伤加重即纳入病情加重组，若无以上改变则纳入病情平稳组，比较组间各指标差异，并绘制受试者工作特征曲线（ROC），评价不同时间点各指标对患者病情进展的预测价值。结果:共入选106例患者，其中病情平稳组89例，病情加重组17例，两组患者基线资料均衡。颅脑损伤患者伤后6 h可出现CRP、CRP/PA升高，PA下降，48 h分别达到峰值或谷值；与病情平稳组比较，病情加重组24、48、72 h CRP/PA显著升高〔24 h：34.18（20.19，67.10）比13.98（4.36，38.30），48 h：71.10（45.55，96.97）比16.02（5.05，41.76），72 h：23.25（4.46，38.61）比4.72（2.38，12.95），均n P<0.05〕。ROC曲线分析显示，伤后24 h及48 h的CRP/PA可作为颅脑外伤患者病情进展的预测指标，24 h CRP/PA的ROC曲线下面积（AUC）为0.71，95%可信区间（95%n CI）为0.58～0.84，截断值为28.29时，敏感度为76.5%，特异度为73.0%；48 h CRP/PA的AUC为0.76，95%n CI为0.62～0.90，截断值为37.18时，敏感度为88.2%，特异度为70.8%。n 结论:成人颅脑外伤后动态监测CRP/PA比值可评估病情，24 h及48 h时的CRP/PA对患者伤后病情进展有预测价值。“,”Objective:To investigate the value of serum Cn -reactive protein/prealbumin ratio (CRP/PA) in predicting the disease progression of adult patients with traumatic brain injury.n Methods:A prospective study was conducted. Patients with traumatic brain injury who were over 18 years old and were followed up for more than 72 hours admitted to the department of emergency of Huashan North Hospital Affiliated to Fudan University from May 2018 to December 2019 were enrolled. The levels of serum CRP, PA were measured immediately after injury and at 6, 24, 48 and 72 hours after injury, and the CRP/PA ratio was calculated. Glasgow coma score (GCS) was dynamically measured and head CT was reviewed regularly. If the GCS decreased by more than 3 and/or the intracranial injury was aggravated by CT scan within 72 hours after injury, the patients were included in the aggravating group. If there were no above changes, they were included in the stable group. The differences of each index between the two groups were compared, and the receiver operating characteristic (ROC) curve was drawn to evaluate the predictive value of each index at different time points on the patient's disease progress.Results:A total of 106 patients were selected, including 89 patients in the stable group and 17 patients in the aggravating group, and the baseline data of the two groups were balanced. CRP, CRP/PA increased and PA decreased in brain trauma patients 6 hours after injury, and reached the peak value or valley value at 48 hours. Compared with the stable group, CRP/PA significantly increased at 24, 48 and 72 hours in the aggravating group [24 hours: 34.18 (20.19, 67.10) vs. 13.98 (4.36, 38.30), 48 hours: 71.10 (45.55, 96.97) vs. 16.02 (5.05, 41.76), 72 hours: 23.25 (4.46, 38.61) vs. 4.72 (2.38, 12.95), all n P < 0.05]. ROC curve analysis showed that CRP/PA ratio at 24 hours and 48 hours after injury could be used as a predictor of disease progression. The area under the ROC curve (AUC) of 24 hours CRP/PA was 0.71, 95% confidence interval (95% n CI) was 0.58-0.84, the cutn -off value was 28.29, the sensitivity was 76.5%, and the specificity was 73.0%. The AUC of 48 hours CRP/PA was 0.76, 95%n CI was 0.62-0.90, and the cutn -off value was 37.18, the sensitivity was 88.2%, and the specificity was 70.8%.n Conclusion:The dynamic monitoring of CRP/PA ratio in adult after traumatic brain injury can evaluate the disease condition, and the CRP/PA ratio of 24 hours and 48 hours can predict the progress of the disease.