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为了便于叙述和理解,我们先简单复习一下疟原虫的生活史。人和其他脊椎动物(如齧齿类、鸟类和爬虫类等)在被蚊叮咬时都有可能感染疟疾。 雌按蚊从受感染的人吸入配子体(game-tocytes)状态的原虫。配子体在蚊体内通过复杂的变化转变为子孢子(sporozoites),后者存在于按蚊的唾液腺中,而由按蚁的叮咬再传播给人类。进入人体的子孢子侵入肝实质细胞,并在肝细胞中转化为裂殖子(merozoites),称为红细胞外期。在肝细胞破裂时裂殖子被释放入血液中,然后侵入红细胞,并在红细胞中繁殖。在破坏宿主红细胞后,裂殖子释入血流中,并侵入其他红细胞,进入红细胞内期的周
In order to facilitate narration and understanding, let’s briefly review the life history of Plasmodium. People and other vertebrates (such as rodents, birds and reptiles, etc.) may be infected with malaria when bitten by mosquitoes. Anopheles anopheles Inhales protozoa from the infected person in the state of game-tocytes. Gametosomes are transformed by complex changes in mosquitoes into sporozoites, which are present in the salivary gland of Anopheles mosquitoes and are transmitted to humans again by bites of the ant. Sporozoites entering the human body invade the liver parenchymal cells and are transformed into merozoites in the liver cells, referred to as the erythrocytic phase. Membranes are released into the bloodstream upon rupture of hepatocytes, then invade erythrocytes and multiply in erythrocytes. After destroying host erythrocytes, merozoites release into the blood stream, and invade other red blood cells into the red blood cells within the week