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１病历摘要患者女性，６９岁。１９９９年１１月无明显诱因出现左下肢胀痛，伴腰痛。２００１年６月上述症状逐渐加重，并出现右下肢、髋关节疼痛，乏力，行走困难。２００１年７月于北京协和医院作骨髓穿刺：骨髓增生活跃，M：E＝４．３：１，粒系比例增高，余未见异常。同时?
1 medical record Summary Female patient, 69 years old. November 1999 no obvious incentive left lower extremity pain, with low back pain. June 2001 the above symptoms gradually aggravated, and the right lower extremity, hip pain, fatigue, difficulty walking. July 2001 in Beijing Union Medical College Hospital for bone marrow biopsy: myeloid hyperplasia, M: E = 4.3: 1, the proportion of grain increased, I no exception. Simultaneously?