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化疗是口腔癌临床治疗的常用方法之一,在口腔癌治疗中发挥了重要的作用。但部分病例化疗后出现疗效不佳现象,表现为机体对化疗药物出现了耐药现象。研究发现多数肿瘤细胞存在内源性和外源性的耐药,这是造成化疗失败的主要原因。相关研究表明口腔癌多药耐药与相关蛋白表达、酶类介导、基因突变等众多因素相关,目前研究热点是针对耐药相关因素进行多药耐药的逆转。
Chemotherapy is one of the commonly used methods of clinical treatment of oral cancer and plays an important role in the treatment of oral cancer. However, some cases of poor efficacy after chemotherapy, manifested as the emergence of the body of chemotherapy drug resistance phenomenon. The study found that most tumor cells have endogenous and exogenous drug resistance, which is the main reason for the failure of chemotherapy. Related studies have shown that oral cancer multidrug resistance and related protein expression, enzyme-mediated, gene mutations and many other factors related to the current research focus is resistance-related factors for the reversal of multidrug resistance.