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目的了解广州地区鱼肉组织中喹诺酮类药物的残留情况。方法于2006年9—10月,在广州市S1～S5地区的5个大型农贸市场采集鳗鱼(Anguilla japonica)、加洲鲈鱼(Micropterus salmoides)、黄鳝(Monopterus albus)和草鱼(Ctenopharyngodon idellus)4种淡水养殖鱼样品。采用反相高效液相色谱法(HPLC)检测4种鱼类体内环丙沙星(ciprofloxacin,CPFX)、诺氟沙星(norfloxacin,NFLX)、恩诺沙星(enrofloxacin,ENFX)的残留量。结果诺氟沙星在采自广州市5个区的4种淡水鱼鱼肉组织中均被检出,检出的含量范围为2.19～192.8 ng/g,平均含量为21.26 ng/g;环丙沙星在鱼肉组织中的检出率为40%,含量范围为0～25.36 ng/g,其平均含量为4.34 ng/g;恩诺沙星在鱼肉组织中的检出率为45%,平均含量为6.83 ng/g。其中,加州鲈鱼和鳗鱼体内3种药物检出率最高,加州鲈鱼肌肉中诺氟沙星、环丙沙星和恩诺沙星检出率分别为100%,40%和100%;鳗鱼肌肉组织中3种药物检出率分别为100%,40%和80%;黄鳝和草鱼肌肉中恩诺沙星检出率都较低,分别为20%和0%。3种药物在肝脏中的平均残留含量要高于其在肌肉中的平均残留含量。结论广州地区鱼肉组织中喹诺酮类药物的残留量基本符合NY 5070—2002《水产品中鱼药残留限量》中的规定。
Objective To understand the residues of quinolones in fish tissues in Guangzhou. Methods From September to October in 2006, four species of Anguilla japonica, Micropterus salmoides, Monopterus albus and Ctenopharyngodon idellus were collected from five large farmer’s markets in S1 ~ S5 area of Guangzhou. Freshwater fish culture samples. The residues of ciprofloxacin (CPFX), norfloxacin (NFLX) and enrofloxacin (ENFX) in four species of fish were detected by reverse-phase high performance liquid chromatography (HPLC) Results Norfloxacin was detected in four kinds of freshwater fish from five districts of Guangzhou. The content ranged from 2.19 to 192.8 ng / g with an average content of 21.26 ng / g. Ciprofloxacin The detection rate of star in fish tissues was 40%, the content range was 0 ~ 25.36 ng / g, the average content was 4.34 ng / g; the detection rate of enrofloxacin in fish tissues was 45%, the average content 6.83 ng / g. Among them, California seabass and eel had the highest detection rate of the three drugs, and the detection rates of norfloxacin, ciprofloxacin and enrofloxacin in California perch muscle were 100%, 40% and 100% respectively. The eel muscle tissue The detection rates of three drugs were 100%, 40% and 80% respectively. The detection rates of enrofloxacin in both eels and grass carp muscles were lower, 20% and 0% respectively. The average residual content of the three drugs in the liver is higher than their average residual content in the muscle. Conclusion The residues of quinolones in fish tissues in Guangzhou are basically in accordance with the requirements of NY 5070-2002, “Limit of Fish Residues in Aquatic Products”.