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NK 细胞作为机体非特异性监视机构之一,作为肿瘤细胞和病毒感染细胞的标志细胞,显示其细胞杀伤活性。其活性用干扰素和干扰素的诱发物质可使其增强。此外,最近还发现NK 细胞对免疫反应的抑制作用。Nabel 等报告了用IL-2培养的小鼠NK 细胞对用脂多糖类诱导的小鼠脾细胞的Ig 产生有抑制作用。笔者用美州商陆有丝分裂原刺激B细胞,NK 细胞抑制B 细胞Ig 的产生。另外,也证明了干扰素活化的NK 细胞直接抑制被EB 病毒感染的B 细胞Ig 的产生。在体外已经证明NK 细胞对抗体产生的抑制作用,但关于自身免疫性疾病和病毒感染中NK 细胞的抗体抑制机能尚有许多不明之处。笔者研究了干扰素和NK 细胞对MRL/1小鼠脾细胞Ig 产生的抑制效果,并测定了空斑形成细胞(PFC)。在脂多糖类存在的情况下,添加干扰素
NK cells, one of the non-specific surveillance institutions of the body, serve as a marker cell for tumor cells and virus-infected cells and show their cytotoxic activity. Its activity with interferon and interferon-induced substances can make it enhanced. In addition, NK cells have recently been found to have an inhibitory effect on the immune response. Nabel et al. Reported that mouse NK cells cultured with IL-2 have an inhibitory effect on Ig production by lipopolysaccharide-induced mouse splenocytes. I used the United States plover mitogen stimulated B cells, NK cells inhibit B cell Ig production. In addition, interferon-activated NK cells were also demonstrated to directly inhibit the production of IgE by B cells infected with Epstein-Barr virus. NK cells have been shown to inhibit antibody production in vitro, but there are many uncertainties about the antibody inhibitory function of NK cells in autoimmune diseases and viral infections. The authors studied the inhibitory effect of interferon and NK cells on the Ig production of splenocytes in MRL / 1 mice and determined plaque-forming cells (PFCs). In the presence of lipopolysaccharide, interferon is added