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目的比较血清中抗环瓜氨酸肽抗体(抗-CCP)和类风湿因子(RF)在类风湿性关节炎中的诊断价值。方法分别用ELISA法和免疫透射比浊法测定抗-CCP和RF值,包括96例RA患者、90例非RA自身免疫性疾病患者和83例健康人。结果 RA组中抗-CCP和RF的阳性率分别为76.0%和88.5%,两者差异有统计学意义(P<0.05);非RA组抗-CCP和RF的阳性率分别为3.3%和48.9%,两者差异有统计学意义(P<0.05);抗-CCP和RF的灵敏度分别为76.0%、88.5%;特异度分别为96.7%,51.1%;阳性预测值分别为96.1%、65.9%;阴性预测值分别为79.1%、80.7%。结论抗-CCP特异度高于RF,但灵敏度低于RF。联合检测抗-CCP与RF可提高对RA诊断的准确性。
Objective To compare the diagnostic value of anti-cyclic citrullinated peptide antibody (anti-CCP) and rheumatoid factor (RF) in rheumatoid arthritis. Methods Anti-CCP and RF values were determined by ELISA and immunoturbidimetric assay, including 96 patients with RA, 90 patients with non-RA autoimmune disease and 83 healthy individuals. Results The positive rates of anti-CCP and RF in RA group were 76.0% and 88.5%, respectively, with statistical significance (P <0.05). The positive rates of anti-CCP and RF in non-RA group were 3.3% and 48.9 %, The difference between the two was statistically significant (P <0.05); the sensitivity of anti-CCP and RF were 76.0% and 88.5% respectively; the specificity were 96.7% and 51.1% respectively; the positive predictive values were 96.1% and 65.9% ; Negative predictive value was 79.1%, 80.7%. Conclusion The anti-CCP specificity is higher than that of RF, but the sensitivity is lower than that of RF. Combined detection of anti-CCP and RF improves the accuracy of RA diagnosis.