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目的:观察柔肝消癥饮对肝硬化大鼠血清一氧化氮(NO)和血浆内皮素-1(ET-1)含量的影响。方法:采用复合因素造模法复制肝硬化大鼠模型,实验分组为正常组、模型组、阳性药(复方鳖甲软肝片)对照组和柔肝消癥饮高、低剂量组。观察柔肝消癥饮对肝硬化大鼠肝组织病理形态学、血清NO和血浆ET-1含量的影响。结果:模型组大鼠出现肝小叶损害,纤维组织增生,假小叶形成;血清NO和血浆ET-1含量以及二者比值显著增加。各治疗组肝脏病理损害较轻,血清NO和血浆ET-1含量以及二者比值明显降低。结论:柔肝消癥饮通过显著抑制肝硬化大鼠血清NO和血浆ET-1水平的异常升高,以达到抗肝硬化的作用。
Objective: To observe the effect of Rougan Xiaozheng Yin on the levels of serum nitric oxide (NO) and endothelin-1 (ET-1) in cirrhotic rats. Methods: The rat models of cirrhosis were established by compound factor modeling. The experimental groups were divided into normal group, model group, positive control group (Fufang Biejia Ruangan Pian) and control group of Rougan Xiaozheng Yin high and low dose groups. To observe the effect of Rougan Xiaozheng Yin on liver histopathology, serum NO and plasma ET-1 in cirrhotic rats. Results: The hepatic lobule damage, fibrous tissue hyperplasia and pseudolobule formation were observed in model group. The content of serum NO and plasma ET-1 and the ratio of them were significantly increased. The pathological lesion of liver in each treatment group was lighter, the content of serum NO and ET-1 in plasma and the ratio of them were significantly decreased. Conclusion: Rougan Xiaozheng Yin can significantly inhibit the abnormal increase of serum NO and plasma ET-1 levels in cirrhotic rats to achieve anti-liver cirrhosis.