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进行性系统性硬化症(PSS)是一种结缔组织病,它不仅有皮肤损害,且各个内脏器官均可受累,其发病机制仍然不明。虽有少数药物对本病有些疗效,般均未能使之完全治愈。作者考虑应用雌三醇(estriol)治疗PSS的依据是:(1)PSS主要发生在女性; (2)妊娠期有时症状减轻; (3)雌三醇是妊娠后期组成尿雌激素的主要部分; (4)雌三醇对分娩期子宫颈有松弛作用; (5)雌三醇能抑制骨质疏松,骨质疏松不仅是衰老的表现,而且是PSS的临床表现之一。就作者所知,尚无应用雌三醇治疗
Progressive systemic sclerosis (PSS) is a connective tissue disease, which not only has skin lesions, and various internal organs can be affected, the pathogenesis is still unknown. Although a small number of drugs on the effectiveness of some of the disease, as they failed to make it completely cured. The authors consider the use of estriol in the treatment of PSS based on: (1) PSS occurs predominantly in females; (2) symptoms are sometimes alleviated during pregnancy; (3) estriol is the predominant component of urinary estrogen in the second trimester of pregnancy; (4) estriol on the cervical cervix during childbirth relaxation; (5) estriol can inhibit osteoporosis, osteoporosis is not only the performance of aging, but also one of the clinical manifestations of PSS. To the author’s knowledge, there is no application of estriol therapy