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目的：研究ＣＰＵ８６０１７及左甲状腺素（Ｌｅｖ）影响内钙释放及钙内流引起血管平滑肌（ＶＳＭ）收缩．方法：以三种大鼠胸主动脉环（ＶＳＭ）收缩，比较ＣＰＵ８６０１７，苄普地尔（Ｂｅｐ），维拉帕米（Ｖｅｒ）及尼莫地平（Ｎｉｍ），在正常及Ｌｅｖ致甲亢大鼠中的抑制作用．结果：ＣＰＵ８６０１７抑制ＫＣｌ收缩正常及甲亢大鼠ＶＳＭ的ＩＣ５０为８０（３６－１７９）及１２１（６２－２３６）μｍｏｌ·Ｌ－１，强度为Ｂｅｐ的１／１０，Ｖｅｒ及Ｎｉｍ的１／１００．Ｖｅｒ及Ｎｉｍ对甲亢大鼠ＶＳＭ在无钙ＫＨ液中抑制活性大幅下降－８６％及－９５％，而ＣＰＵ８６０１７及Ｂｅｐ几乎无改变．ＣＰＵ８６０１７在正常及甲亢大鼠中对钙内流的抑制强度无改变．结论：ＣＰＵ８６０１７抑制大鼠ＶＳＭ钙内流强于钙释放，而Ｌｅｖ加强二者．
OBJECTIVE: To study the effects of CPU86017 and Lev on the release of calcium and the influx of calcium to cause the contraction of vascular smooth muscle (VSM). Methods: Three kinds of rat thoracic aortic rings (VSM) were contracted. Compared with CPU86017, Bep, Ver and Nim, Inhibition in rats. Results: The IC50 of CPU86017 for inhibition of KCl contractions and hyperthyroidism in VSMCs were 80 (36-179) and 121 (62-236) μmol·L-1, respectively, with intensity of 1/10 of Bep, Ver / Nim 1 / 100. Ver and Nim on hyperthyroid rat VSM in calcium-free KH inhibition activity decreased sharply -86% and -95%, while CPU 86017 and Bep almost no change. CPU 86017 in normal and hyperthyroid rat inhibition of calcium influx intensity did not change. Conclusion: CPU86017 inhibits calcium influx in rat VSM stronger than calcium, while Lev strengthens both.