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目的分析及观察他汀类药(氟伐他汀)对尿毒症血液透析患者微炎症状态及血尿酸水平的临床疗效。方法选择襄樊市第一人民医院透析中心49例行透析3年以上的患者为观察对象,分别对照治疗前及氟伐他汀治疗24周后血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高敏C反应蛋白(hs-CRP)、白介素6(IL-6)和血尿酸。结果血液透析患者存在高炎症状态,经过氟伐他汀治疗24周后,血液透析患者的血LDL-C、hs-CRPI、L-6和尿酸水平均有显著降低,与治疗前比较,有显著性差异(P<0.05)。结论他汀类药能明显改善血液透析患者的微炎症状态及血尿酸水平。
Objective To analyze and observe the clinical effect of statins (fluvastatin) on micro-inflammatory status and serum uric acid in hemodialysis patients with uremia. Methods Forty-nine dialysis centers in the First People’s Hospital of Xiangfan City for more than three years were enrolled in this study. The levels of total cholesterol (TC), triglyceride (TG), triglyceride LDL-C, hs-CRP, IL-6 and serum uric acid. Results Hemodialysis patients had a high inflammatory state. After treatment with fluvastatin for 24 weeks, the levels of LDL-C, hs-CRPI, L-6 and uric acid in hemodialysis patients were significantly lower than those before treatment Difference (P <0.05). Conclusion Statins can significantly improve the micro-inflammatory status and serum uric acid level in hemodialysis patients.