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目的观察不同剂量的异烟肼治疗结核性脑病的临床效果及其治疗后引起的不良反应。方法将2010年1月到2012年3月入住我院接受治疗的结核性脑膜炎患者84例随机分为观察组和对照组,观察组56例在常规治疗的基础上给予不用剂量的异烟肼联合地塞米松治疗。对照组只是进行常规治疗。比较两组患者的临床效果、该病症状缓解的时间及患者的预后情况。结果观察组与对照组治疗的有效率相比,观察组比对照组明显的优势,P<0.01;观察组患者症状缓解的时间明显要比对照组短,P<0.05;观察组患者出现不良反应的几率要比对照组低,P<0.01;差异具有统计学意义。结论异烟肼与地塞米松联合治疗结核性脑膜炎可以明显地缩短患者治疗的时间,提高临床疗效。有助于改善患者预后的情况,同时可以减少不良反应的发生。
Objective To observe the clinical effects of different doses of isoniazid in the treatment of tuberculous encephalopathy and its adverse effects after treatment. Methods 84 cases of tuberculous meningitis admitted to our hospital from January 2010 to March 2012 were randomly divided into observation group and control group. 56 cases in observation group were given no dose of isoniazid Combined dexamethasone treatment. The control group was treated only routinely. The clinical effects of the two groups were compared, the time to alleviate the symptoms and the prognosis of the patients. Results Compared with the control group, the observation group had a significant advantage over the control group (P <0.01); the time to relieve the symptoms in the observation group was significantly shorter than that in the control group (P <0.05), and adverse reactions in the observation group The odds of lower than the control group, P <0.01; the difference was statistically significant. Conclusion Isoniazid combined with dexamethasone in the treatment of tuberculous meningitis can significantly shorten the treatment time and improve clinical efficacy. Help to improve the prognosis of patients, at the same time can reduce the incidence of adverse reactions.