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目的探讨甘露醇应用前后闪光视觉诱发电位(fVEP)N2波的变化趋势及其与颅内压变化之间的关系。方法选择52例高颅压患者,将其分为单用甘露醇组和合用甘油氯化钠组,两组分别为32例及20例。应用NIP-200型无创颅内压监测仪测定第1、4、10次应用甘露醇前后fVEP N2波潜伏期及波幅,并进行比较。结果单用甘露醇组甘露醇应用后30 m in N2波潜伏期开始缩短,在应用后2 h时缩至最短,4 h时N2波潜伏期有所回升,但仍较甘露醇应用前短。N2波波幅差异无统计学意义。随着甘露醇应用次数的增多,N2波潜伏期缩短的程度逐渐降低。合用甘油氯化钠降颅压组甘露醇应用前后N2波潜伏期变化不明显。结论甘露醇应用前后fVEP N2波潜伏期发生了变化,提示fVEP N2波潜伏期的变化可以反映颅内压的变化趋势。
Objective To investigate the change trend of fVEP N2 wave before and after mannitol administration and its relationship with changes of intracranial pressure. Methods Fifty-two patients with intracranial hypertension were divided into single mannitol group and combined glycerol sodium chloride group, 32 cases and 20 cases in both groups. NIP-200 noninvasive intracranial pressure monitor was used to determine the latency and amplitude of fVEP N2 wave before and after mannitol administration in the first, the fourth and the tenth times, and compared. Results After incubation with mannitol, the incubation time of 30 m in N2 began to shorten and reached the shortest at 2 h after application. The latency of N2 wave rebounded at 4 h but still short compared with that of mannitol. N2 wave amplitude difference was not statistically significant. With the increase of mannitol application frequency, the degree of N2 wave latency shortening gradually decreased. Combined with glycerin sodium chloride intracranial pressure group mannitol before and after application of N2 wave latency was not obvious. Conclusion Before and after the application of mannitol, the latency of fVEP N2 wave changed, suggesting that the change of latency of fVEP N2 wave may reflect the changing trend of intracranial pressure.