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目的研究小剂量心律平、胺碘酮、安搏律定三药合用抗心律失常作用。方法舌下ｉｖ乌头碱（Ａｃ）诱发大鼠心律失常，观察心律平（Ｐｒｏ）、胺碘酮（Ａｍｉ）、安搏律定（Ａｐｒ）单用及合用对心律失常的作用。结果每日单独使用Ｐｒｏ１２０ｍｇ·ｋｇ－１、Ａｍｉ４０ｍｇ·ｋｇ－１、Ａｐｒ２０ｍｇ·ｋｇ－１可推迟Ａｃ诱发的室性心律失常出现时间及缩短其持续时间；而Ｐｒｏ４０ｍｇ·ｋｇ－１、Ａｍｉ２０ｍｇ·ｋｇ－１、Ａｐｒ４ｍｇ·ｋｇ－１无显著抗心律失常作用；联合应用Ｐｒｏ２６０ｍｇ·ｋｇ－１、Ａｍｉ１３０ｍｇ·ｋｇ－１及Ａｐｒ２６ｍｇ·ｋｇ－１则有显著抗心律失常作用。结论三药联合应用不仅可保持一定疗效，也可大大减少各药剂量。
Objective To study the effects of low-dose heart rhythm, amiodarone and anti-arrhythmic combination of three anti-arrhythmic drugs. Methods The subacute iv aconitine (Ac) -induced arrhythmia was observed in rats. The effects of proarrhythmia, amiodarone and amiodarone on the arrhythmia were observed. Results The daily use of Pro120mg · kg-1, Ami40mg · kg-1 and Apr20mg · kg-1 could delay the onset of Ac-induced ventricular arrhythmia and shorten the duration of the treatment. However, Pro40mg · kg-1, Ami20mg · kg- 1, Apr4mg · kg-1 had no significant anti-arrhythmic effect. The combination of Pro260mg · kg-1, Ami130mg · kg-1 and Apr26mg · kg-1 had significant anti-arrhythmic effect. Conclusion The combination of three drugs can not only maintain a certain effect, but also greatly reduce the dose of each drug.