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非酒精性脂肪性肝病(NAFLD)是最常见的肝病,部分患者通过脂肪性肝炎进展为肝硬化和肝癌。NAFLD还与2型糖尿病和心血管疾病高发独立相关。NAFLD患者病死率增高,心血管疾病对其预后的影响与肝病同样重要。临床上,NAFLD患者需常规行代谢紊乱检查,并兼顾防治肝脏和心血管并发症。有关NAFLD诊断的研究进展迅速,然而肝活检仍是金标准。改变生活方式是治疗的首选方法和主要措施,减肥和改善胰岛素抵抗非常重要。暂不推荐保肝药物用于NAFLD的常规治疗。
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease, and some patients progress to cirrhosis and liver cancer through steatohepatitis. NAFLD is also independently associated with a high incidence of type 2 diabetes and cardiovascular disease. The mortality of NAFLD patients increases, the prognosis of cardiovascular disease and liver disease are equally important. Clinically, patients with NAFLD routine metabolic metabolic disorder check, and take into account the prevention and treatment of liver and cardiovascular complications. Research on NAFLD has progressed rapidly, but liver biopsy remains the gold standard. Changing lifestyles is the treatment of choice and the main measures to lose weight and improve insulin resistance is very important. Temporarily does not recommend the use of hepatoprotective drugs for routine treatment of NAFLD.