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采用郭峰等人的方法，进行了四君子汤对荷瘤小鼠红细胞免疫功能影响的体内实验研究。结果表明：四君子汤能明显提高荷瘤小鼠的RBC-C3bRR和RFER，降低RBC-ICRR和RFIR。这一结果表明四君子汤对荷瘤小鼠红细胞免疫有显著的促进作用。
Using Guo Feng et al.’s method, the effect of Sijunzi Decoction on red blood cell immune function in tumor-bearing mice was studied in vivo. The results showed that Sijunzi Decoction can significantly increase RBC-C3bRR and RFER in tumor-bearing mice, and decrease RBC-ICRR and RFIR. This result shows that Sijunzi Decoction has a significant role in promoting red blood cell immunity in tumor-bearing mice.