论文部分内容阅读
目的:探讨特发性血小板减少性紫癜的治疗转归与巨细胞病毒感染的关系。为临床合理有效地治疗ITP提供部分参考。方法:用ELISA法和流式细胞仪分别检测患儿血清HCMV抗体及外周血淋巴细胞亚群。选取2005.1-2006.12在本院儿科就诊的68例新发ITP患儿,将其按有无HCMV感染分为HCMV感染组和非感染组,比较二者的免疫状态,近期(两周)疗效,远期(六月)疾病转归之间的关系。结果:68例ITP患儿中HCMV感染30例,非HCMV感染ITP存在T淋巴细胞亚群的异常,即CD4+细胞减低,CD8+细胞升高。HCMV感染患儿T淋巴细胞总数亦降低,CD4+细胞下降明显。近期疗效无明显差异,远期转归相比较有统计学意义。结论:HCMV感染诱发的细胞免疫异常是儿童ITP发病及病程迁延的重要因素。应同时进行抗病毒和免疫治疗。
Objective: To investigate the relationship between treatment outcome of idiopathic thrombocytopenic purpura and cytomegalovirus infection. Provide a partial reference for the clinical rational and effective treatment of ITP. Methods: Serum HCMV antibodies and peripheral blood lymphocyte subsets were detected by ELISA and flow cytometry respectively. Sixty-eight new-onset ITP patients were selected from our pediatric department in 2005.1-2006.12 and divided into HCMV infection group and non-infection group by HCMV infection-free status. The immune status of the two groups were compared, and the recent (two weeks) efficacy was far Period (June) the relationship between disease outcomes. Results: There were 30 HCMV infections in 68 children with ITP. There was abnormal T lymphocyte subsets in ITP infected with non-HCMV virus, ie CD4 + cells decreased and CD8 + cells increased. The total number of T lymphocytes in children with HCMV infection also decreased, CD4 + cells decreased significantly. No significant difference in the recent efficacy, long-term prognosis was statistically significant. Conclusion: The abnormal cellular immunity induced by HCMV infection is an important factor in the pathogenesis and progression of ITP in children. Antiviral and immunotherapy should be carried out simultaneously.