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本文首次报告50例EB病毒VCA-IgA抗体阴性鼻咽癌病人的临床特征及远期疗效。50例病人中,颈淋巴阴性(No)病人占58%(29/50)其中T1-2NoMo病人19例。本组病人5年生存率66%,10年生存率54%.较高的生存率与No病例多有关。随着N分期的升级,生存率下降。T3-4NoMo病人给予较高剂量照射,其10年生存率为33.3%;T分期较早病人给予低剂量照射,也获得较高的生存率,提示不同了分期的病人需要不同的放射剂量。本文还总结、讨论了此类病人的临床症状,抗体阴性可能原因及诊断方法。
This article first reported 50 cases of Epstein-Barr virus VCA-IgA antibody-negative patients with nasopharyngeal carcinoma clinical features and long-term efficacy. Of the 50 patients, 58% (29/50) had cervical lymphatic negative (No), and 19 had T1-2NoMo. This group of patients 5-year survival rate of 66%, 10-year survival rate of 54%. Higher survival rates are related to No cases. With the escalation of N staging, the survival rate decreased. T3-4NoMo patients given higher doses of irradiation, the 10-year survival rate was 33.3%; T stage earlier patients given low-dose irradiation, also obtained a higher survival rate, suggesting that different staging patients need different doses of radiation . This article also summarizes and discusses the clinical symptoms of such patients, the possible causes of antibody negative and diagnostic methods.