非甾体抗炎药物 ( NSAID)是一类具有重要临床应用价值的药物 ,其化学结构类型多样化 ,多数结构是手性分子。 NSAID对映异构体在药效、毒性和动力学性质上存在差别 ,而除了少数药物外 ,临床应用的手性 NSAID是其外消旋体。 NSAID主要通过抑制环氧化酶起药理作用 ,而某些手性 NSAID抑制环氧化酶的作用主要是其 S 构型。因此在手性 NSAID产品中是否应该有 R 构型是一值得讨论的问题。 Non-steroidal anti-inflammatory drugs (NSAIDs) are a group of drugs with important clinical value. Their chemical structure types are diversified, most of them are chiral molecules. NSAID enantiomers differ in their pharmacodynamic, toxicological and kinetic properties, with the exception of few drugs, which are clinically useful chiral NSAIDs as their racemates. NSAID mainly through the inhibition of cyclooxygenase pharmacological effects, and some chiral NSAID inhibition of cyclooxygenase role is mainly its S configuration. Therefore, whether R configuration should be present in chiral NSAID products is a topic worth discussing.