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临床资料 ①病例选择与分组 选择我院1993年3月至1999年3月的急性重度有机磷中毒病例78例,随机分为两组,观察组40例,男9例,女31例;对照组38例,男8例,女30例。两组均为消化道中毒,年龄16～56岁,入院时间为30～90min。②治疗方法 两组病例均彻底洗胃,清洗污染部位,切断毒源,吸氧、输液及保持呼吸道通畅等治疗。观察组病人入院即给解磷注射液2～3支肌注,以后酌情每30min至12h肌注1支至治愈。对照组病人入院即给阿托品5～20mg静注,以后每10～30min静注2～5mg,阿托品化后每2～6h肌注1mg至治愈,并给予碘解磷定1g静注,用3次。③观察指标与治愈标准 观察中毒症状消失情况,胆碱酯酶(CHE)活力恢复程度及有无反跳现象和抢救成功率。治愈标准:中毒症状消失,CHE活力恢复正常。初步脱离危险:中毒症状消失,CHE活力恢复正常水平50％。
Clinical data ① case selection and group selection of our hospital from March 1993 to March 1999 acute severe organophosphorus poisoning 78 cases were randomly divided into two groups, the observation group 40 cases, 9 males and 31 females; control group 38 cases, 8 males and 30 females. Both groups were gastrointestinal poisoning, aged 16 to 56 years old, admission time was 30 ~ 90min. ② treatment two groups of patients were thoroughly gastric lavage, clean the contaminated site, cut off the source of poison, oxygen, infusion and maintain airway patency and other treatment. Patients in the observation group were given 2 to 3 intramuscular injection of Phosphate-Soluble Injection, and intramuscular injection of 1 to 30 days after the injection was given as appropriate. Patients in control group were given intravenous injection of atropine 5 ~ 20mg intravenously after every 10 ~ 30min intravenous injection of 2 ~ 5mg, atropine after every 2 ~ 6h intramuscular injection of 1mg to cure and given intravenous iodine phosphate 1g, with 3 times . ③ observation indicators and cure criteria observed the disappearance of symptoms of poisoning, the degree of recovery of cholinesterase (CHE) vitality and whether the phenomenon of rebound and rescue success rate. Healing criteria: poisoning symptoms disappear, CHE vitality returned to normal. The initial danger of danger: poisoning symptoms disappear, CHE vitality returned to normal levels of 50%.