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骨肉瘤的传统疗法是高位截肢,关节离断。预后很差,据统计五年生存率只有5—20％。自1972年Jaffe和Coites发表临床应用超大剂量氨甲碟呤以来,将五年生存率提高达36—77％该组收治二例股骨远端骨肉瘤,治疗方法是:盐酸氮芥动脉区域灌注,肿瘤切除灭活再植,超大剂量氨甲喋呤化疗,甲酰四氢叶酸钙抢救(HD—MTX—CF)不仅保住了肢体,而且患者上下樓不用付木,近期疗效满意。
The traditional treatment for osteosarcoma is high amputation and disconnection of joints. The prognosis is very poor. According to statistics, the five-year survival rate is only 5-20%. Since Jaffe and Coites published the clinical application of a large dose of methotrexate in 1972, the five-year survival rate has been increased by 36-77%. This group treats two cases of distal femoral osteosarcoma. The treatment is: arterial perfusion of nitrogen mustard artery, Inactivation of tumor replantation, large doses of methotrexate chemotherapy, and calcium folinate-formaldehyde rescue (HD-MTX-CF) not only saved the limbs, but also the patients did not have to pay for the wood up and down the stairs, and the recent results were satisfactory.