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目的：进一步了解创伤性脑水肿的发生机理和探索其治疗方法。方法：将１８只家兔随机分为３组：标准对照组（组１）、实验对照组（组２）、１，６－二磷酸果糖（ＦＤＰ）治疗组（组３）。取损伤前及损伤后不同时间的颈内静脉血、伤后３ｈ大脑皮质，测定观察指标。结果：组３大脑皮层的丙二醛（ＭＤＡ）含量和水含量、颈内静脉血液中ＭＤＡ浓度均较组２低（Ｐ＜０．０１）；大脑皮层的光、电镜观察显示：组３的损伤程度较组２轻。结论：ＦＤＰ对创伤性脑水肿有一定的治疗作用，表现为：抑制氧化磷酸化过程、减轻脑水肿和保护神经元生物膜的完整性
Objective: To further understand the mechanism of traumatic brain edema and explore its treatment. Methods: Eighteen rabbits were randomly divided into three groups: standard control group (group 1), experimental control group (group 2) and fructose 1,6 - diphosphate (FDP) treatment group (group 3). The jugular venous blood before injury and at different time after injury were collected, and the cerebral cortex was harvested 3 hours after injury. Results: The content of MDA and water in the cerebral cortex of group 3 and the content of MDA in the blood of jugular vein were lower than those of group 2 (P <0.01). The light and electron microscopy of cerebral cortex showed that the content of MDA Damage than Group 2 light. Conclusion: FDP has a certain therapeutic effect on traumatic brain edema. It can inhibit the process of oxidative phosphorylation, relieve cerebral edema and protect the integrity of neuronal biofilm