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目的对比观察阿托伐他汀、辛伐他汀、瑞舒伐他汀治疗高血脂合并老年动脉粥样硬化性急性脑梗死患者的临床疗效。方法高血脂合并老年动脉粥样硬化性急性脑梗死患者126例,随机分为辛伐他汀组(A组)42例、阿托伐他汀组(B组)40例、瑞舒伐他汀组(C组)44例。在常规治疗的基础上,三组分别给予口服用药,疗程均为2周,对各组入院第2天及治疗2周后的血糖、血脂、肝功能、血清肌酸激酶(CK)等指标进行对比。结果治疗2周后,三组患者治疗后血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)低于治疗前,高密度脂蛋白胆固醇(HDL-C)高于治疗前,差异均有统计学意义(P<0.05),三组患者治疗后TC、LDL-C、HDL-C组间比较,差异均有统计学意义(P<0.05)。结论缺血性卒中的二级预防应从急性期就开始使用降脂药物,常规剂量使用他汀类药物治疗高血脂合并老年动脉粥样硬化性急性脑梗死患者不良反应发生率低,只要合理地应用,长期使用他汀类药是比较安全的。
Objective To compare the clinical effects of atorvastatin, simvastatin and rosuvastatin in patients with hyperlipidemia and senile atherosclerotic cerebral infarction. Methods A total of 126 hypertensive patients with senile atherosclerotic cerebral infarction were randomly divided into simvastatin group (group A) 42 cases, atorvastatin group (group B) 40 cases, rosuvastatin group (C Group) 44 cases. On the basis of routine treatment, the three groups were given oral medication, the course of treatment was 2 weeks, on the 2nd day after admission and 2 weeks after treatment, blood glucose, blood lipids, liver function, serum creatine kinase (CK) Compared. Results After treatment for two weeks, the levels of total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) in the three groups after treatment were lower than those before treatment and HDL-C were higher than before treatment (P <0.05). There was significant difference between TC, LDL-C and HDL-C after treatment in three groups (P <0.05). Conclusion Secondary prevention of ischemic stroke should be started from the acute phase of lipid-lowering drugs, the conventional dose of statins for treatment of hyperlipidemia in elderly patients with atherosclerotic acute cerebral infarction with a low incidence of adverse reactions, as long as the rational application, Long-term use of statins is safer.