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为了观察局部注射蓝染脂质体在乳腺癌手术中腋窝淋巴结(ALN)及前哨淋巴结(SLN)检测较单用显色剂的优势,利用脂质体-美蓝混合物以及单用美蓝对68例临床Ⅰ、Ⅱ期乳腺癌患者进行前哨淋巴结活检(SLNB)及ALN的清除,均经病理检查,了解两种染色剂在淋巴结染色的灵敏度、准确性方面的差异。脂质体美蓝组36例,成功确定SLN 34例,成功率为94.4%(34/36);SLN阳性16例(47.1%),SLN阴性18例(53%);ALN阳性17例(47.2%),ALN阴性19例(52.8%);SLNB的灵敏度为94.1%,准确性为91.7%。美蓝组32例,成功确定SLN 29例,成功率为90.6%(29/32);SLN阳性11例(37.9%),SLN阴性18例(62.1%);ALN阳性13例(43.8%),ALN阴性18例(56.3%);SLNB的灵敏度为84.6%,准确性为84.4%。两组比较在检查SLNB的灵敏度和准确性方面差异有统计学意义,P<0.05。初步研究结果提示,蓝染脂质体应用于乳腺癌术中,具有淋巴结易着色,可以提高SLNB的成功率、灵敏度及准确性等优点。
In order to observe the advantages of local injection of blue-stained liposomes in the detection of axillary lymph nodes (ALN) and sentinel lymph nodes (SLN) in breast cancer surgery compared with single color reagent, liposome-methylene blue mixture and methylene blue Cases of clinical stage Ⅰ, Ⅱ breast cancer patients sentinel lymph node biopsy (SLNB) and ALN clearance, both by pathological examination to understand the two stains in lymph node staining sensitivity and accuracy differences. The success rate of SLN was 34.4% (34/36). SLN positive was 16 (47.1%), SLN negative was 18 (53%), ALN was positive (47.2%) %), ALN negative in 19 cases (52.8%); SLNB sensitivity was 94.1%, the accuracy of 91.7%. The success rate was 90.6% (29/32) in SLN patients. The SLN positive rate was 11 (37.9%), the SLN negative rate was 18 (62.1%), and the ALN positive rate was 13.8% (43.8% ALN negative in 18 cases (56.3%); SLNB sensitivity was 84.6%, the accuracy of 84.4%. There was a significant difference between the two groups in the sensitivity and accuracy of SLNB examination, P <0.05. Preliminary results suggest that the blue-staining liposomes used in breast cancer surgery, with lymphatic stained easily, can improve the success rate of SLNB, sensitivity and accuracy and so on.