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目的:探讨乙型肝炎患者血清腺苷酸脱氨酶(ADA)、透明质酸(HA)、层黏蛋白(LN)、Ⅳ型胶原(C-Ⅳ)及Ⅲ型前胶原(PCⅢ)检测的临床意义。方法:选择选择2011年8月至2012年12月海南省人民医院收治的30例乙型肝炎患者作为观察组.同期38例健康体检者作为正常对照组.分别检测两组血清ADA活性,HA、LN、C-Ⅳ、PCⅢ水平。结果:观察组患者血清ADA活性、HA、LN、C-Ⅳ、PCⅢ水平明显高于正常对照组(P<0.01)。结论:乙型肝炎患者血清ADA的活性与HA、LN、C-Ⅳ、PCⅢ水平的变化可反映肝脏损伤程度和肝纤维化趋势,对早期诊断治疗及预后判断有重要的临床价值。
Objective: To investigate the detection of serum adenylate aminotransferase (ADA), hyaluronic acid (HA), laminin (LN), type Ⅳ collagen and type Ⅲ procollagen (PC Ⅲ) Clinical significance. Methods: Thirty patients with hepatitis B who were admitted to Hainan Provincial People’s Hospital from August 2011 to December 2012 were selected as the observation group.Among the 38 healthy people were selected as normal control group, serum ADA activity, HA, LN, C-Ⅳ, PCⅢ level. Results: Serum ADA activity, HA, LN, C-IV and PCIII levels in the observation group were significantly higher than those in the normal control group (P <0.01). Conclusion: The changes of serum ADA and the levels of HA, LN, C-Ⅳ and PCⅢ in patients with hepatitis B can reflect the degree of hepatic injury and the tendency of hepatic fibrosis. It has important clinical value in early diagnosis, treatment and prognosis.