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目的:探讨抗-IFN与IFN治疗病毒性肝炎疗效的关系。方法:采用ELISA法检测32例慢性病毒性肝炎患者治疗前后血清抗-IFN。结果:IFN治疗后3个月、6个月,抗-IFN阳性率分别为28.1％、31.1％,其阳性率明显高于治疗前(6.3％),使用不同类型IFN,产生抗-IFN情况也有差别。用IFN治疗3个月、6个月后,抗-IFN阳性者,HBV-DNA或HCV-RNA阴转率分别为22.2％(2/9)、20.0％(2/10);而阴性者,则分别为43.4％(10/23)、54.5％(12/22),后者的阴转率较前者高,治疗前抗-INF已阳性的2例病人HBV-DNA均没有阴转。结论:抗-IFN可能是影响干扰素疗效的因素。
Objective: To investigate the relationship between anti-IFN and IFN in the treatment of viral hepatitis. Methods: Serum anti-IFN was measured in 32 patients with chronic viral hepatitis before and after treatment by ELISA. Results: The positive rates of anti-IFN were 28.1% and 31.1% at 3 months and 6 months after IFN treatment respectively. The positive rates of anti-IFN were significantly higher than those before treatment (6.3% difference. The anti-IFN-positive, HBV-DNA or HCV-RNA negative conversion rates were 22.2% (2/9) and 20.0% (2/10) for 3 months and 6 months after treatment with IFN, (43.4%, 10/23) and 54.5% (12/22), respectively. The negative rate of the latter was higher than that of the former. HBV-DNA of the two patients with positive anti-INF before treatment did not have any negative conversion. Conclusion: Anti-IFN may be the factor that affects the efficacy of interferon.