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合成并表征了新的小肽配体N -(S- 三苯甲基巯基乙酰基)丙氨酰甘氨酰甘氨酸(Tr- MAAG2 ).通过直接标记法制备了水溶性配合物99mTc -MAAG2,并对其体外稳定性进行了检测.研究了配合物99mTc- MAAG2 在荷瘤鼠体内的生物分布以及血液清除,结果表明,99mTc- MAAG2 在肿瘤和肌肉中的质量摄取率am之比为2. 67,肿瘤和血液的am之比为0.75,血液清除较快.
A new small peptide ligand, N - (S-tritylmercaptoacetyl) alanylglycylglycine (Tr-MAAG2), was synthesized and characterized. The water-soluble complex 99mTc-MAAG2 was prepared by direct labeling, And the in vitro stability of 99mTc-MAAG2 was studied.The biodistribution and blood clearance of 99mTc-MAAG2 in tumor-bearing mice were studied.The results showed that the ratio of 99mTc-MAAG2 to tumor mass and muscle mass am was 2. 67, tumor and blood am ratio of 0.75, blood clearance faster.