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开胸狗18只,用轉子流速計連續测量冠状动脉左旋枝流量。冠状动脉內注射苯乙肼25微克/公斤或股靜脉滴注5毫克/公斤都增加冠脉流量,降低冠脉阻力,扩張冠脉。苯乙肼5毫克/公斤/天連續皮下注射5天(“苯乙肼化”)則冠脉流量略减少而冠脉阻力稍增高,因此扩張冠脉不是它治疗心絞痛的基础。苯乙肼不加强5-羥基色胺和去甲腎上腺素的扩張冠脉作用,也不对抗脑垂体后叶素的收縮冠脉作用,它对利血平化狗的作用与正常者无明显差別,且其作用快而短,說明它不是通过抑制单胺氧化酶而产生其心血管效应。推测苯乙肼急性給药的扩張冠脉作用可能是它本身直接作用于腎上腺素能受体的結果;注射5天后能节約心肌耗氧,提示它治疗心絞痛可能与影响心肌代謝有关。
Thoracotomy dogs 18, continuous measurement of left ventricular branch flow with a rotameter. Intra-coronary injection of phenelzine 25 μg / kg or femoral vein infusion of 5 mg / kg both increased coronary flow, decreased coronary resistance, and dilated coronary arteries. Phenelzine 5 mg / kg / day Subcutaneously 5 days (“phenelzamide”) slightly reduced coronary flow and slightly increased coronary resistance, so dilation of the coronary arteries is not the basis for its treatment of angina. Phenelzine does not strengthen the dilated coronary effects of 5-hydroxytryptamine and norepinephrine, nor does it antagonize the contractile coronary effect of pituitrin, which has no effect on reserpine-treated dogs Difference, and its role is fast and short, indicating that it does not produce monoamine oxidase and its cardiovascular effects. It is speculated that the acute coronary artery administration of phenelzine may be the result of its direct action on the adrenergic receptor; 5 days after injection can save myocardial oxygen consumption, suggesting that it may be related to the impact on myocardial metabolism and angina pectoris.