人类的许多肿瘤均有染色体17p13等位基因丢失,其中乳腺癌靶基因可能位于17p13.3与17p13.1之间的区域,普遍认为位于17p13.1的P53为靶基因。已知P53错义突变可稳定其基因产物;并能造成P53过度表达,而P53点突变则是肿瘤形成的常见特征。免疫组织化学方法检测发现乳腺癌的P53蛋白水平升高,这反映了体细胞的高突变率。为证实P53位点的杂合性丢失(LOH)和蛋自过度表达有无关联,作者 Many human tumors have chromosome 17p13 alleles lost, and the breast cancer target gene may be located in the region between 17p13.3 and 17p13.1. It is generally believed that P53 located at 17p13.1 is the target gene. It is known that P53 missense mutations can stabilize their gene products; and can cause overexpression of P53, while P53 point mutations are common features of tumor formation. Immunohistochemical detection revealed elevated levels of P53 protein in breast cancer, reflecting the high mutation rate of somatic cells. To confirm whether loss of heterozygosity at the P53 locus (LOH) is associated with overexpression of eggs, the authors