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目的:探讨自体骨髓基质干细胞(BMSCs)组织工程复合物治疗骨囊肿的临床疗效。方法:对18例骨囊肿患者以玻璃酸钠为载体抽取自体BMSCs加入甲基强的松龙,在X线透视下,将2根骨穿针经皮分别自囊腔顶部和底部刺入骨囊肿内,抽去囊液,冲洗囊腔后注入复合物。其中14例注射1次,4例注射2次间隔2～3个月。结果:本组病例随访时间10～18个月,平均14个月,骨愈合良好,无复发及并发症。根据Neer和Chrigira的X线评价骨囊肿愈合标准进行评估,本组18例治疗10个月后均达到Ⅳ级,平均治疗2～3个月后大部分病例囊腔出现硬化骨,密度增高,透光区开始模糊;3～4个月后囊腔大部分消失,残留小而模糊囊腔;5～6个月后囊腔进一步缩小,少数囊腔已消失;8～9个月后囊腔骨皮质变厚,骨小梁及部分髓腔开始贯通,绝大多数囊腔基本消失;10个月后骨囊腔完全愈合,治愈率100%。18例骨囊腔愈合时间3～10个月,平均5个月。结论:本方法治疗骨囊肿疗效确切、方法简单、不需手术、创伤最小、痛苦最轻、无并发症、费用较低、患儿及家长易于接受,是目前安全有效、治愈率最高、便于基层医院推广使用的一种最新型治疗方法。
Objective: To investigate the clinical efficacy of autologous bone marrow stromal cells (BMSCs) tissue engineering composite in the treatment of bone cysts. Methods: 18 cases of patients with bone cysts were taken sodium hyaluronate as the carrier to extract autologous BMSCs methylprednisolone, under X-ray fluoroscopy, 2 bone percutaneous needle percutaneous cysts were pierced from the top and bottom of the cyst Within, pumping cyst fluid, flushing the cyst into the complex. Among them, 14 cases were injected once and 4 cases were injected 2 times at intervals of 2 to 3 months. Results: The patients were followed up for 10 to 18 months with an average of 14 months. The bone healing was good without recurrence and complications. According to Neer and Chrigira X-ray evaluation of bone cyst healing criteria, the group of 18 patients reached grade IV after 10 months of treatment, the average treatment of 2 to 3 months after the majority of cases cystic sclerosis, increased density, through After 3 to 4 months, most of the cystic cavity disappeared, leaving small and fuzzy capsule cavity; 5 to 6 months after the cyst cavity further reduced, a few cysts have disappeared; 8 to 9 months after the cystic cavity Cortical thickening, trabecular bone and part of the medullary cavity began through, the vast majority of cysts disappeared; 10 months after the bone cyst completely healed, the cure rate was 100%. 18 cases of bone cavity healing time of 3 to 10 months, an average of 5 months. Conclusion: The method is effective and effective for the treatment of bone cyst. The method is simple, without surgery, minimal trauma, the least pain, no complications, low cost, easy to accept in children and parents, is currently safe and effective, the cure rate is the highest, Hospital to promote the use of a new type of treatment.