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目的:应用弥散张量磁共振成像定量分析大脑胶质瘤的特点。方法:11例经病理证实的大脑胶质瘤患者,行弥散张量磁共振成像检查,在ADC图和FA图上分别测量肿瘤周围水肿区域、肿瘤强化区域、囊变区域、脑脊液及对侧正常大脑白质ADC值和FA值。结果:肿瘤周围水肿区域的ADC值和FA值与肿瘤囊变区域、脑脊液及对侧大脑白质相比较均有显著性差异(P<0.05),而与肿瘤强化区域相比较无显著性差异。肿瘤囊变区域的ADC值及FA值与脑脊液、对侧正常大脑白质相比较有显著性差异(P<0.05);肿瘤囊变区域与肿瘤强化区域相比较,ADC值无显著性差异,FA值却有显著性差异(P<0.05)。肿瘤强化区域的ADC值及FA值与对侧大脑白质相比较具有显著性差异(P<0.05)。高、低级别胶质瘤肿瘤周围水肿区域、肿瘤强化区域、肿瘤囊变区域的ADC值及FA值均无统计学显著差异。结论:磁共振弥散张量成像对定量分析大脑胶质瘤本身及其周围脑组织具有重要价值。
Objective: To quantitatively analyze the characteristics of brain glioma with diffusion tensor magnetic resonance imaging. Methods: Totally 11 cases of pathologically confirmed gliomas were examined by diffusion tensor MR imaging. The ADC, FA maps were used to measure the area around the tumor, tumor area, cystic area, cerebrospinal fluid and contralateral normal Brain white matter ADC value and FA value. Results: The ADC value and FA value of tumor surrounding edema area were significantly different from those of tumor cystic area, cerebrospinal fluid and contralateral white matter (P <0.05), but no significant difference compared with tumor strengthening area. ADC values and FA values of tumor cystic areas were significantly different from those of cerebrospinal fluid and contralateral normal white matter (P <0.05). There was no significant difference in ADC value between tumor cystic areas and tumor-enhanced areas. FA value But there was significant difference (P <0.05). The ADC value and FA value of the tumor enhancement area were significantly different from the contralateral white matter (P <0.05). There was no significant difference in the ADC values and FA values between the high and low grade gliomas around the tumor, the tumor strengthening area and the tumor cystic area. Conclusion: MR diffusion tensor imaging is of great value for quantitative analysis of brain glioma itself and surrounding brain tissue.