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目的 探讨金石散溶解胆石的药效特点及作用规律。方法 采用金石散胶囊治疗胆石症 70例 ,以B超检查、T管逆行造影结果作治疗前后对比 ,观察胆汁性状 ,测定胆汁中过氧化脂质 (LPO)浓度。结果 非手术组 5 3例中胆囊结石 17例 ,服药后结石变化不大 ,但症状可明显缓解 ;肝内胆管结石 36例 ,结石消失 8例 ,变小或减少 14例 ,无效 14例 ,总有效率为6 1 1%。手术组 17例中 ,服药后见胆汁中胆红素沉淀或胆砂石均消失 ,其中 5例为术后再发胆总管结石 ,随访 4a未再发。胆汁中过氧化脂质 (LPO)测定 ,金石散具有降低胆汁中LPO浓度的作用。结论 金石散具有溶解胆石及降低胆汁中LPO浓度的作用
Objective To investigate the pharmacodynamic characteristics and action of dissolving gallstone in Jinshisan. Methods 70 cases of cholelithiasis were treated with Jinshisan capsule. The results of B-ultrasound and T-tube retrograde contrast were compared before and after treatment. Bile traits were observed and the concentration of lipid peroxide (LPO) in bile was measured. Results In the non-surgical group, there were 17 cases of gallstones in 53 cases. The stones were not changed after taking the medicine, but the symptoms were relieved obviously. There were 36 cases of intrahepatic bile duct stones, 8 stones disappeared, 14 cases were reduced or decreased, and 14 cases were invalid. The effective rate is 61 1%. Among the 17 patients in the surgical group, bile bilirubin precipitation or gallstones disappeared after taking the drug, and 5 of them were common bile duct stones after operation. No follow-up was found during follow-up 4a. Determination of lipid peroxidation (LPO) in bile, Jinshisan has the effect of reducing the concentration of LPO in bile. Conclusion Jinshisan has the effect of dissolving gallstones and decreasing the concentration of LPO in bile