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很久以来,人们一直怀疑饮食在神经管缺陷的发生估计可起一定作用。1964年有人提出,发病可能与叶酸(一种B族维生素)有关。1980年和1981年发表了两项干预性研究(intervention study)的结果,但由于研究未随机化,服用的是包括叶酸在内的多种维生素混合剂,或者由于研究规模小、没有适当的对照组,所以未能得出肯定性结论。自1983年7月至1991年4月,在7个国家33个中心进行了一项随机双盲预防试验,以确定怀孕前后补充叶酸或另外7种维生素的混合物能否预防神经管缺陷。
It has long been suspected that diet may play a role in the estimation of neural tube defects. It was suggested in 1964, the incidence may be related to folic acid (a B vitamins). The results of two intervention studies were published in 1980 and 1981 but due to the non-randomized study, vitamin supplements, including folic acid, were either administered or, due to the small study size, no appropriate controls Group, so failed to reach a positive conclusion. From July 1983 to April 1991, a randomized double-blind prevention trial was conducted in 33 centers in seven countries to determine whether the combination of folic acid supplementation with another seven vitamins before and after pregnancy could prevent neural tube defects.