皮克氏病(Pick’s病)是一种以痴呆为主要表现的神经变性疾病,发病年龄多在50～60岁之间.病理改变为额叶和颞叶萎缩,镜下改变为神经元缺失、胶质细胞增生及出现皮克细胞和皮克小体.临床表现上同AD难以鉴别.病理主要靠发现皮克细胞和皮克小体,但如果没有发现上述特征,即使在病理上也是难以鉴别的.βA_4是由42个氨基酸组成的蛋白质,一直被 Pick’s disease is a kind of neurodegenerative disease with dementia as the main manifestation, the age of onset is mostly between 50 and 60. The pathological changes are the frontal lobe and the temporal lobe atrophy, the microscopic change to the neuron loss, Glial cell proliferation and the emergence of Pique cells and Pickett’s body. Clinical manifestations with the AD is difficult to identify. Pathological mainly by the discovery of Pick’s cells and Pick’s body, but if you do not find the above characteristics, even in the pathological is difficult to identify ΒA_4 is a 42 amino acid protein that has been