Kaempferol-5-O-α-L-rhamnopyranoside(1)与Kaempferol-3,5-di-O-α-L-rhamnopyranoside(2)是一类具有代表性的黄酮醇5位鼠李糖的天然化合物.由于5位羟基具有较强的分子内氢键,传统的糖苷化条件不能高效合成.本工作使用全新的糖苷化方法,以糖基邻炔基苯甲酸酯作给体,一价金作催化剂,高效的构建了山奈酚5位的糖苷键,并完成了天然产物1和2的合成. Kaempferol-5-O-α-L-rhamnopyranoside (1) and Kaempferol-3,5-di-O-α-L-rhamnopyranoside (2) are representative compounds of natural flavonol 5-position rhamnose Because of the strong intramolecular hydrogen bonding of the 5-hydroxyl group, the traditional glycosylation conditions can not be efficiently synthesized.In this work, a new glycosylation method was used to glycosyl ortho-alkynyl benzoate as donor, Catalyst, the glycosidic bond at the 5-position of kaempferol was efficiently constructed and the synthesis of the natural products 1 and 2 was completed.