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目的建立一种检测血清中肿瘤标志物CA19-9、CA72-4和MG7-Ag的方法,并探讨3种肿瘤指标对胃癌的诊断意义。方法采用电化学发光法与酶免法分别检测200例正常人,170例III期胃癌行根治术的患者进行术前及术后每两个月检测患者血清CA19-9、CA72-4和MG7-Ag,术后定期进行常规复查。结果全组中有101例患者发现了复发(其中血源性复发83例,局部复发18例),复发患者CA19-9、CA72-4和MG7-Ag敏感度分别为62.3%、67.3%和59.4%,3项联合检测的敏感度为95.0%。结论联合检测CA19-9、CA72-4和MG7-Ag可以提高特异性,并有助于预测胃癌术后复发,3项标志物联合检测可早期诊断胃癌。
Objective To establish a method for the detection of tumor markers CA19-9, CA72-4 and MG7-Ag in serum and to investigate the significance of the three tumor markers in the diagnosis of gastric cancer. Methods Electrochemiluminescence and enzyme-linked immunosorbent assay were used to detect the serum levels of CA19-9, CA72-4 and MG7-MS in 200 normal subjects and 170 patients with stage III gastric cancer undergoing radical operation. Ag, regular postoperative regular review. Results 101 of the patients in the whole group were found to have recurred (83 of them had blood-borne recurrence and 18 of local recurrence). The sensitivity of CA19-9, CA72-4 and MG7-Ag in recurrence patients were 62.3%, 67.3% and 59.4 %, The sensitivity of three joint tests was 95.0%. Conclusions The combined detection of CA19-9, CA72-4 and MG7-Ag can improve the specificity and predict the recurrence of gastric cancer. The combined detection of three markers can early diagnose gastric cancer.