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目的 :为了解新生儿缺氧缺血性脑病 ( HIE)时血浆内皮素 ( ET)及一氧化氮 ( NO)的变化。方法 :分别采用放射免疫法和硝酸还原酶法测定新生儿 HIE急性期 40例、恢复期 2 0例及 2 0例对照组病人的血浆 ET和 NO的水平 ,采用统计学 t检验方法进行分析。结果 :新生儿 HIE急性期血浆 ET及 NO均显著升高 ,且 ET升高的程度高于 NO升高的程度。HIE恢复期两者均下降 ,与对照组比较无显著差异。在轻重程度不同的 HIE中 ,ET值随病情加重而升高 ,NO值却随病情加重而降低 ,各组间均无显著差异。结论 :在 HIE急性期 ,ET和 NO对其发病均起了重要作用 ,二者相比 ET占据主导地位。而 NO除细胞毒性作用外 ,尚有保护性作用
Objective: To investigate the changes of plasma endothelin (ET) and nitric oxide (NO) in neonates with hypoxic-ischemic encephalopathy (HIE). Methods: Plasma ET and NO levels in 40 neonates with acute HIE, 20 in convalescence and 20 controls were measured by radioimmunoassay and nitrate reductase method, respectively. Statistical analysis was performed using t-test. Results: The levels of plasma ET and NO in neonates with acute HIE were significantly increased, and the levels of ET were higher than those of NO. HIE recovery period both decreased, compared with the control group no significant difference. In HIE with different degrees of severity, the ET value increased with the aggravation of the disease, while the NO value decreased with the aggravation of illness. There was no significant difference among the groups. Conclusions: In the acute phase of HIE, ET and NO play an important role in the pathogenesis, both of which play a dominant role compared with ET. NO in addition to cytotoxic effects, there is a protective effect