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目的探讨Ｃ－ｅｒｂＢ２和表皮生长因子（ＥＧＦＲ）蛋白表达与垂体腺瘤激素类型及侵袭性的关系。方法用免疫组化ＡＢＣ法对６４例垂体腺瘤进行Ｃ－ｅｒｂＢ２和ＥＧＦＲ免疫染色。结果Ｃ－ｅｒｂＢ２和ＥＧＦＲ仅在大多数无激素型腺瘤中阳性表达，而在其它激素类型腺瘤病中极少阳性表达。ＥＧＦＲ在侵袭性腺瘤中的阳性表达率（４１．９３％）高于非侵袭组（１２．１２％），两者差异有显著性（Ｐ＜０．０５）。结论Ｃ－ｅｒｂＢ２和ＥＧＦＲ过度表达可能与无激素型腺瘤的发生有关，而ＥＧＦＲ在垂体腺瘤的侵袭性行为中可能起重要作用
Objective To investigate the relationship between the expression of C-erbB2 and epidermal growth factor (EGFR) protein and the type and invasiveness of pituitary adenomas. Methods 64 cases of pituitary adenoma were immunohistochemically stained for C-erbB2 and EGFR by immunohistochemical ABC method. Results C-erbB2 and EGFR were positively expressed only in most hormone-free adenomas and rarely positively expressed in other hormone-type adenomas. The positive expression rate of EGFR in invasive adenomas (41.93%) was higher than that in non-invasive ones (12.12%). There was a significant difference between them (P<0.05). Conclusion Overexpression of C-erbB2 and EGFR may be related to the development of hormone-free adenomas, and EGFR may play an important role in the invasive behavior of pituitary adenomas.