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1 作用和适应症粒细胞—巨噬细胞集落刺激因子(granulocyte-macrophage colony stimulating factor)Sargramostim是天然产生的胞质活动糖蛋白,现可通过重组DNA技术生产。本刺激因子可刺激粒细胞—巨噬细胞增殖、分化和功能活化,临床上用于非何杰金氏淋巴瘤、急性淋巴细胞性白血病、或何杰金氏病患者于自体骨髓移植中或以后加速患者骨髓的恢复。 2 禁忌症急性骨髓母细胞性白血病、骨髓发育不全综合征以及骨髓或周围血中白血病髓样细
1 Effects and indications Granulocyte-macrophage colony stimulating factor Sargramostim is a naturally occurring cytoplasmic glycoprotein that can now be produced by recombinant DNA technology. This stimulatory factor stimulates granulocyte-macrophage cell proliferation, differentiation, and functional activation and is clinically used in patients with non-Hodgkin’s lymphoma, acute lymphoblastic leukemia, or Hodgkin’s disease during or after autologous bone marrow transplantation. Accelerate the recovery of patients’ bone marrow. 2 Contraindications Acute myeloid leukemia, bone marrow agenesis syndrome, and bone marrow or peripheral blood leukemia medulloid